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Version: 17.06d (Release date: 2017-06-26)
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FGFR Inhibitor TAS-120 (Code C114283)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: FGFR Inhibitor TAS-120

Definition: An orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) with potential antineoplastic activity. FGFR inhibitor TAS-120 selectively and irreversibly binds to and inhibits FGFR, which may result in the inhibition of both the FGFR-mediated signal transduction pathway and tumor cell proliferation, and increased cell death in FGFR-overexpressing tumor cells. FGFR is a receptor tyrosine kinase essential to tumor cell proliferation, differentiation and survival and its expression is upregulated in many tumor cell types.

Label: FGFR Inhibitor TAS-120

NCI Thesaurus Code: C114283 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471791  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
FGFR Inhibitor TAS-120
TAS-120

External Source Codes: 
PDQ Closed Trial Search ID 757896
PDQ Open Trial Search ID 757896 (check for NCI PDQ open clinical trial info)
NCI META CUI CL471791

Other Properties:
     Name Value (qualifiers indented underneath)
code C114283
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C114283

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