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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Carboxyamidotriazole (Code C1141)

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Terms & Properties

Preferred Name: Carboxyamidotriazole

Definition: An orally-active agent with potential antineoplastic activity. Carboxyamidotriazole binds to and inhibits non-voltage-operated Ca2+ channels, blocking both Ca2+ influx into cells and Ca2+ release from intracellular stores and resulting in the disruption of calcium channel-mediated signal transduction and inhibition of vascular endothelial growth factor (VEGF) signaling, endothelial proliferation, and angiogenesis. This agent may also inhibit tumor cell growth, invasion and metastasis. (NCI04)

NCI-GLOSS Definition: An anticancer drug that belongs to the family of drugs called angiogenesis inhibitors.

Display Name: Carboxyamidotriazole

Label: Carboxyamidotriazole

NCI Thesaurus Code: C1141 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0064494  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-1,2,3-Triazole-4-carboxamide, 5-amino-1-((3,5-dichloro-4(4-chlorobenzoyl)phenyl)methyl)

External Source Codes: 
CAS Registry Number 99519-84-3 (see NLM ChemIDplus info)
NSC Code 609974 (see NCI DTP info)
PDQ Closed Trial Search ID 41613
PDQ Open Trial Search ID 41613 (check for NCI PDQ open clinical trial info)
UMLS CUI C0064494

Other Properties:
     Name Value (qualifiers indented underneath)
code C1141
Contributing_Source CTRP
Legacy_Concept_Name Carboxyamidotriazole
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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