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National Cancer Institute
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Version: 17.10e (Release date: 2017-10-30)
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KW-2149 (Code C1140)

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Terms & Properties

Preferred Name: KW-2149

Definition: A semisynthetic water-soluble disulfide derivative of the antineoplastic antibiotic mitomycin C. Activated by serum and glutathione, KW-2149 causes interstrand DNA cross-links and DNA-protein cross-links, resulting in single-strand DNA breaks and inhibition of DNA synthesis. (NCI04)

Label: KW-2149

NCI Thesaurus Code: C1140 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0064443  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
7-N-(2-((2-(gamma-L-Glutamylamino)ethyl)dithio)ethyl)mitomycin C
KW 2149

External Source Codes: 
CAS Registry Number 118359-59-4 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 42572
PDQ Open Trial Search ID 42572 (check for NCI PDQ open clinical trial info)
UMLS CUI C0064443

Other Properties:
     Name Value (qualifiers indented underneath)
code C1140
Legacy_Concept_Name KW-2149
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  


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