skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Carbon C11 Temozolomide (Code C113806)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Carbon C11 Temozolomide

Definition: A radioconjugate composed of temozolomide, a imidazotetrazine analog of dacarbazine, labeled with the radioisotope carbon C11, with potential positron emission tomography (PET) imaging activity. As a cytotoxic alkylating agent, temozolomide is hydrolyzed at physiologic pH to the pharmacologically active compound, 5-(3-methyl-(triazen-1-yl)-imidazole)-4-carboxamide (MTIC). MTIC is further hydrolyzed to 5-aminoimidazole-4-carboxamide (AIC) and a methyldiazonium cation. The cation is able to methylate DNA, particularly at the O6 and N7 positions of guanine residues, resulting in cell cycle arrest, inhibition of DNA replication and the induction of apoptosis. Temozolomide is metabolized to MITC at all sites, crosses the blood-brain-barrier and penetrates well into the central nervous system. Upon PET, the biodistribution, uptake in cancer cells and the efficacy of temozolomide can be assessed.

Display Name: Carbon C11 Temozolomide

Label: Carbon C11 Temozolomide

NCI Thesaurus Code: C113806 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471788  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
[11C] Temozolomide
Carbon C11 Temozolomide

External Source Codes: 
PDQ Closed Trial Search ID 757878
PDQ Open Trial Search ID 757878 (check for NCI PDQ open clinical trial info)
NCI META CUI CL471788

Other Properties:
     Name Value (qualifiers indented underneath)
code C113806
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113806

Mainbox Bottom