skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Itraconazole (Code C1138)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Itraconazole

Definition: A synthetic triazole agent with antimycotic properties. Formulated for both topical and systemic use, itraconazole preferentially inhibits fungal cytochrome P450 enzymes, resulting in a decrease in fungal ergosterol synthesis. Because of its low toxicity profile, this agent can be used for long-term maintenance treatment of chronic fungal infections. (NCI04)

NCI-GLOSS Definition: A drug used to prevent or treat fungal infections. It belongs to the family of drugs called antifungal agents.

Display Name: Itraconazole

Label: Itraconazole

NCI Thesaurus Code: C1138 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0064113  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
(+-)-1-sec-Butyl-4-(p-(4-(p-(((2R*,4S*)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl)methoxy)phenyl)-1-piperazinyl)phenyl)-delta(sup 2)-1,2,4-triazolin-5-one
Itraconazole
ITRACONAZOLE
itraconazole
Lozanoc
Oriconazole
R 51,211
Sporanox

External Source Codes: 
CAS Registry Number 84625-61-6 (see NLM ChemIDplus info)
FDA UNII Code 304NUG5GF4
ChEBI ID CHEBI:6076 (see ChEBI info)
PDQ Closed Trial Search ID 39106
PDQ Open Trial Search ID 39106 (check for NCI PDQ open clinical trial info)
UMLS CUI C0064113

Other Properties:
     Name Value (qualifiers indented underneath)
Accepted_Therapeutic_Use_For Fungal Infections
Chemical_Formula C35H38Cl2N8O4
code C1138
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Itraconazole
Semantic_Type Antibiotic
Semantic_Type Organic Chemical

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1138

Mainbox Bottom