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Version: 17.06d (Release date: 2017-06-26)
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Uncaria tomentosa Extract (Code C113799)

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Terms & Properties

Preferred Name: Uncaria tomentosa Extract

Definition: An extract of Uncaria tomentosa (U. tomentosa), also called Cat's claw, a native Amazonian plant belonging to the Rubiaceae species, with potential anti-inflammatory, immunomodulating, antioxidant and antineoplastic activities. Although the exact mechanism(s) by which U. tomentosa extract exerts its effect(s) has yet to be fully elucidated, this extract may inhibit the proliferation of certain types of cancer cells. This extract may modulate inflammatory and immune responses through the stimulation of T- and B-lymphocytes and certain cytokines, including interleukin (IL)-1, IL-6 and tumor necrosis factor-alpha (TNF-a). Components in U. tomentosa may both induce repair of chemically-induced DNA damage and scavenge free radicals, which may protect against reactive oxygen species (ROS)-mediated cellular damage. In addition, this extract stimulates myelopoiesis, which may prevent chemotherapy-induced neutropenia.

Label: Uncaria tomentosa Extract

NCI Thesaurus Code: C113799 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0939876  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cat's Claw Herbal Extract
Uncaria tomentosa Extract

External Source Codes: 
PDQ Closed Trial Search ID 757651
PDQ Open Trial Search ID 757651 (check for NCI PDQ open clinical trial info)
UMLS CUI C0939876

Other Properties:
     Name Value (qualifiers indented underneath)
code C113799
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113799

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