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Version: 17.06d (Release date: 2017-06-26)
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Globulin Component Macrophage-activating Factor (Code C113798)

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Terms & Properties

Preferred Name: Globulin Component Macrophage-activating Factor

Definition: A recombinant form of GC (group-specific component) protein-derived macrophage-activating factor (GC-MAF) with potential immunostimulating and antineoplastic activities. Upon administration, globulin component macrophage-activating factor is able to stimulate macrophages to kill cancer cells, inhibit angiogenesis and stimulate the immune system. This decreases tumor cell proliferation. GC, also known as vitamin D binding protein (VDBP), is converted to GC-MAF by enzymes located in the membrane of B- and T-lymphocytes. However, deglycosylated GC protein cannot be converted to GC-MAF. Endogenous GC-MAF is often not activated in patients with cancer due to an increased activity of nagalase (also called alpha-N-acetylgalactosaminidase), an enzyme secreted by cancer cells that mediates the deglycosylation of GC; thus preventing macrophage activation and immunosuppression.

Label: Globulin Component Macrophage-activating Factor

NCI Thesaurus Code: C113798 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0530774  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GC-MAF
GcMAF
GC Protein-derived Macrophage-activating Factor
Globulin Component Macrophage-activating Factor

External Source Codes: 
PDQ Closed Trial Search ID 757647
PDQ Open Trial Search ID 757647 (check for NCI PDQ open clinical trial info)
UMLS CUI C0530774

Other Properties:
     Name Value (qualifiers indented underneath)
code C113798
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113798

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