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Version: 17.06d (Release date: 2017-06-26)
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Immediate-release Onapristone (Code C113795)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Immediate-release Onapristone

Definition: An immediate-release (IR) formulation of onapristone, an orally bioavailable progesterone receptor (PR) antagonist, with antineoplastic activity. Onapristone binds to the PR and inhibits both PR activation and the associated expression of PR-responsive genes. This may inhibit PR-mediated proliferative effects in cancer cells overexpressing PR. PR is expressed on certain cancer cell types and plays a key role in proliferation and survival.

Label: Immediate-release Onapristone

NCI Thesaurus Code: C113795 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471777  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Immediate-release Onapristone
IR Onapristone

External Source Codes: 
PDQ Closed Trial Search ID 757590
PDQ Open Trial Search ID 757590 (check for NCI PDQ open clinical trial info)
NCI META CUI CL471777

Other Properties:
     Name Value (qualifiers indented underneath)
code C113795
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113795

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