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Version: 17.06d (Release date: 2017-06-26)
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CD133 Antigen Peptide-pulsed Autologous Dendritic Cell Vaccine (Code C113794)

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Terms & Properties

Preferred Name: CD133 Antigen Peptide-pulsed Autologous Dendritic Cell Vaccine

Definition: A cell-based cancer vaccine comprised of autologous dendritic cells (DCs) pulsed with human leukocyte antigen (HLA)-A2-restricted peptides derived from the CD133 antigen, with potential antineoplastic activity. Upon intradermal administration, the CD133 antigen peptide-pulsed autologous DC vaccine may stimulate an anti-tumoral cytotoxic T-lymphocyte (CTL) response against CD133-expressing tumor cells, resulting in tumor cell lysis. CD133, a cancer stem cell marker, is expressed on hematopoietic stem and progenitor cells and overexpressed on many types of cancer cells; it is associated with resistance to chemotherapy and increased cancer survival. HLA-A2 is an MHC class I molecule that presents antigenic peptides to CD8+ T-cells. Epitope design that is restricted to those epitopes that bind most efficiently to HLA-A2 may improve antigenic peptide immunogenicity.

Label: CD133 Antigen Peptide-pulsed Autologous Dendritic Cell Vaccine

NCI Thesaurus Code: C113794 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471775  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CD-133 Dendritic Cell Vaccine
CD133 Antigen Peptide-pulsed Autologous Dendritic Cell Vaccine
CD133 DC Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 757487
PDQ Open Trial Search ID 757487 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C113794
Semantic_Type Immunologic Factor
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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