skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Akt/ERK Inhibitor ONC201 (Code C113792)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Akt/ERK Inhibitor ONC201

Definition: A water soluble, orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) and extracellular signal-regulated kinase (ERK), with potential antineoplastic activity. Upon administration, Akt/ERK inhibitor ONC201 binds to and inhibits the activity of Akt and ERK, which may result in inhibition of the phosphatidylinositol 3-kinase (PI3K)/Akt signal transduction pathway as well as the mitogen-activated protein kinase (MAPK)/ERK-mediated pathway. This may lead to the induction of tumor cell apoptosis mediated by tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL)/TRAIL death receptor type 5 (DR5) signaling in AKT/ERK-overexpressing tumor cells. The PI3K/Akt signaling pathway and MAPK/ERK pathway are upregulated in a variety of tumor cell types and play a key role in tumor cell proliferation, differentiation and survival by inhibiting apoptosis. In addition, ONC201 is able to cross the blood-brain barrier.

Label: Akt/ERK Inhibitor ONC201

NCI Thesaurus Code: C113792 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3710983  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Akt/ERK Inhibitor ONC201
ONC201
TIC10

External Source Codes: 
PDQ Closed Trial Search ID 757339
PDQ Open Trial Search ID 757339 (check for NCI PDQ open clinical trial info)
UMLS CUI C3710983

Other Properties:
     Name Value (qualifiers indented underneath)
code C113792
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113792

Mainbox Bottom