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Version: 17.06d (Release date: 2017-06-26)
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PH20 Hyaluronidase-expressing Adenovirus VCN-01 (Code C113790)

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Terms & Properties

Preferred Name: PH20 Hyaluronidase-expressing Adenovirus VCN-01

Definition: An oncolytic, replication-competent adenovirus encoding the human glycosylphosphatidylinositol-anchored enzyme PH20 hyaluronidase with potential antitumor activity. After intratumoral administration, PH20 hyaluronidase-expressing adenovirus VCN-01 selectively replicates in tumor cells, which may both cause oncolytic virus-induced cell death and induce the infection of adjacent tumor cells. In addition, the virus expresses hyaluronidase, which hydrolyzes and degrades the hyaluronic acid (HA) that coats tumor cells. The degradation of HA may result in a decrease for both the viscosity of the interstitial space and the tumor's interstitial fluid pressure (IFP). This increases viral spread and may result in the inhibition of tumor cell growth. In addition, HA degradation facilitates the penetration of chemotherapeutic agents into the tumor. HA is a glycosaminoglycan found in the extracellular matrix (ECM) and is frequently overproduced by various tumor cell types. The presence of HA in tumors correlates with increases in tumor cell growth, metastatic potential, tumor progression and resistance to chemotherapeutic agents.

Label: PH20 Hyaluronidase-expressing Adenovirus VCN-01

NCI Thesaurus Code: C113790 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL471771  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Genetically Modified Adenovirus-encoding Human PH20 Hyaluronidase VCN-01
PH20 Hyaluronidase-expressing Adenovirus VCN-01

External Source Codes: 
PDQ Closed Trial Search ID 757334
PDQ Open Trial Search ID 757334 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C113790
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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