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Version: 17.12d (Release date: 2017-12-26)
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Immediate-release Tablet Afuresertib (Code C113658)

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Terms & Properties

Preferred Name: Immediate-release Tablet Afuresertib

Definition: An immediate-release (IR) tablet formulation containing afuresertib, an inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Upon oral administration of the IR formulation, afuresertib binds to and inhibits the activity of Akt, which may result in the inhibition of PI3K/Akt signaling pathway, decreased tumor cell proliferation and the induction of tumor cell apoptosis in Akt-expressing tumor cells. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents.

Label: Immediate-release Tablet Afuresertib

NCI Thesaurus Code: C113658 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458371  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GSK2110183 IR Tablet
Immediate-release Tablet Afuresertib
IR Afuresertib

External Source Codes: 
PDQ Closed Trial Search ID 757069
PDQ Open Trial Search ID 757069 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C113658
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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