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Version: 17.06d (Release date: 2017-06-26)
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Carboxylesterase-expressing Allogeneic Neural Stem Cells (Code C113657)

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Terms & Properties

Preferred Name: Carboxylesterase-expressing Allogeneic Neural Stem Cells

Definition: A preparation of allogeneic neural stem cells (NSC), derived from a human fetal cell line, that are adenovirally-transduced to express a modified form of the human enzyme carboxylesterase (CE) hCE1m6, with potential adjuvant activity. Upon intracranial administration, NSCs localize to tumor sites, due to their tumor-trophic nature, and transiently express hCE1m6. Intravenous co-administration of the prodrug irinotecan allows for the selective conversion by hCE1m6 to its active metabolite and topoisomerase I inhibitor, SN-38, in the vicinity of tumor sites. This leads to a local anti-neoplastic effect and causes reduced toxicity and increased therapeutic efficacy of irinotecan. Since NSCs freely cross the blood-brain barrier, these cells can also be intravenously administered to target brain tumor cells. hCE1m6 shows increased activity as compared to unmodified human CE.

Display Name: Carboxylesterase-expressing Allogeneic Neural Stem Cells

Label: Carboxylesterase-expressing Allogeneic Neural Stem Cells

NCI Thesaurus Code: C113657 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458370  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Carboxylesterase-expressing Allogeneic Neural Stem Cells
CE-secreting Allogeneic NSCs
hCE1m6-NSC

External Source Codes: 
PDQ Closed Trial Search ID 756935
PDQ Open Trial Search ID 756935 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458370

Other Properties:
     Name Value (qualifiers indented underneath)
code C113657
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113657

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