skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Long-acting Release Pasireotide (Code C113656)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Long-acting Release Pasireotide

Definition: A long-acting release (LAR) formulation containing pasireotide, a synthetic long-acting cyclohexapeptide, with somatostatin-like activity. Upon intramuscular administration of the LAR formulation of pasireotide, this somatostatin analog strongly binds to and activates somatostatin receptor (SSTR) subtypes 1, 2, 3, and 5. This leads to an inhibition in the secretion of human growth hormone (hGH) and results in decreased production of insulin-like growth factor (IGF-1), which may inhibit IGF-1-mediated cell signaling pathways. This may lead to an inhibition in tumor cell growth and an increase in apoptosis in IGF-1-overexpressing tumor cells. In addition, this agent causes a reduction in adrenocorticotropic hormone (ACTH), which leads to an inhibition of cortisol secretion. ACTH-producing tumors cause hypersecretion of cortisol which results in many unwanted symptoms. This agent may also block other key survival pathways such as the phosphatidylinositol 3-kinase (PI3K) and the mitogen-activated protein kinase (MAPK) signaling pathways. Pasireotide also inhibits vascular endothelial growth factor (VEGF) secretion, thereby decreasing angiogenesis and tumor cell growth in VEGF-overexpressing tumor cells. The long-acting form of pasireotide allows for less frequent administration as compared to the original form of this agent. SSTRs are overexpressed by some neuroendocrine and non-neuroendocrine tumor cells.

Display Name: Long-acting Release Pasireotide

Label: Long-acting Release Pasireotide

NCI Thesaurus Code: C113656 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458369  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
LAR Pasireotide
Long-acting Release Pasireotide
SOM230 LAR

External Source Codes: 
PDQ Closed Trial Search ID 756940
PDQ Open Trial Search ID 756940 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458369

Other Properties:
     Name Value (qualifiers indented underneath)
code C113656
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113656

Mainbox Bottom