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Version: 17.06d (Release date: 2017-06-26)
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Midazolam-containing Buccal Liquid (Code C113654)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Midazolam-containing Buccal Liquid

Definition: An oromucosal solution containing the maleate salt form of midazolam, a short-acting benzodiazepine derivative, with anxiolytic, hypnotic, anticonvulsant and sedative activities. Upon administration of the solution into the buccal cavity, midazolam exerts its effect by binding to the benzodiazepine receptor at the gamma-aminobutyric acid (GABA) receptor-chloride ionophore complex in the central nervous system (CNS). This leads to an increase in the permeability of chloride channels, membrane hyperpolarization and enhances the inhibitory effect of GABA in the CNS. Midazolam may also interfere with the reuptake of GABA, thereby causing accumulation of GABA in the synaptic cleft. The oromucosal formulation facilitates administration to patients that are unable to swallow. The ethanol in this formulation improves the buccal absorption of midazolam.

Label: Midazolam-containing Buccal Liquid

NCI Thesaurus Code: C113654 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458367  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Epistatus
Midazolam-containing Buccal Liquid

External Source Codes: 
PDQ Closed Trial Search ID 756929
PDQ Open Trial Search ID 756929 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458367

Other Properties:
     Name Value (qualifiers indented underneath)
code C113654
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113654

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