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Version: 17.06d (Release date: 2017-06-26)
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gp96-secreting Allogeneic Bladder Cancer Cell Vaccine HS-410 (Code C113653)

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Terms & Properties

Preferred Name: gp96-secreting Allogeneic Bladder Cancer Cell Vaccine HS-410

Definition: An allogeneic urothelial bladder cancer cell vaccine expressing a recombinant secretory form of the immunoadjuvant heat shock protein gp96 fused with an immunoglobulin Fc domain (gp96-Ig) protein, with potential antineoplastic activity. Upon administration of the gp96-Ig-secreting allogeneic bladder cancer cell vaccine HS-410, the live, irradiated tumor cells continuously secrete gp96-Ig along with its chaperoned tumor associated antigens (TAAs). This enhances antigen cross presentation to cytotoxic T-lymphocytes (CTLs) and, upon expansion, leads to the induction of a potent CTL response against the TAAs on the endogenous bladder cancer cells. This vaccine also induces a memory T cell response that could fight recurring cancer cells. gp96-Ig is constructed by replacing the KDEL endoplasmic reticulum (ER) retention sequence of gp96 with the Fc portion of the IgG1 protein. This allows for gp96, normally an ER-resident chaperone peptide, to be released from cells.

Label: gp96-secreting Allogeneic Bladder Cancer Cell Vaccine HS-410

NCI Thesaurus Code: C113653 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458366  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
gp96-secreting Allogeneic Bladder Cancer Cell Vaccine HS-410
HS-410

External Source Codes: 
PDQ Closed Trial Search ID 756851
PDQ Open Trial Search ID 756851 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458366

Other Properties:
     Name Value (qualifiers indented underneath)
code C113653
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113653

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