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National Cancer Institute
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Version: 17.06d (Release date: 2017-06-26)
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Ovapuldencel-T (Code C113651)

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Terms & Properties

Preferred Name: Ovapuldencel-T

Definition: A cancer vaccine consisting of autologous dendritic cells (DCs) loaded with autologous, lethally irradiated cancer cells and mixed with the cytokine granulocyte-macrophage colony stimulating factor (GM-CSF), with potential immunostimulatory and antineoplastic activities. Upon vaccination, ovapuldencel-T may stimulate the immune system to exert a cytotoxic T-lymphocyte (CTL) immune response against the repertoire of tumor associated antigens (TAAs) found in the irradiated cancer cells. GM-CSF enhances the activation of dendritic cells (DCs) and promotes antigen presentation to both B- and T-lymphocytes.

Label: Ovapuldencel-T

NCI Thesaurus Code: C113651 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458364  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)

External Source Codes: 
PDQ Closed Trial Search ID 756846
PDQ Open Trial Search ID 756846 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C113651
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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