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Version: 17.06d (Release date: 2017-06-26)
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LSD1 Inhibitor GSK2879552 (Code C113646)

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Terms & Properties

Preferred Name: LSD1 Inhibitor GSK2879552

Definition: An orally available, irreversible, inhibitor of lysine specific demethylase 1 (LSD1), with potential antineoplastic activity. Upon administration, GSK2879552 binds to and inhibits LSD1, a demethylase that suppresses the expression of target genes by converting the dimethylated form of lysine at position 4 of histone H3 (H3K4) to mono- and unmethylated H3K4. LSD1 inhibition enhances H3K4 methylation and increases the expression of tumor-suppressor genes. This may lead to an inhibition of cell growth in LSD1-overexpressing tumor cells. LSD1, overexpressed in certain tumor cells, plays a key role in tumor cell growth and survival.

Display Name: LSD1 Inhibitor GSK2879552

Label: LSD1 Inhibitor GSK2879552

NCI Thesaurus Code: C113646 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3827120  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
GSK2879552
LSD1 Inhibitor GSK2879552

External Source Codes: 
PDQ Closed Trial Search ID 756742
PDQ Open Trial Search ID 756742 (check for NCI PDQ open clinical trial info)
UMLS CUI C3827120

Other Properties:
     Name Value (qualifiers indented underneath)
code C113646
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113646

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