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Version: 17.12d (Release date: 2017-12-26)
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Inosine Dialdehyde (Code C1136)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Inosine Dialdehyde

Definition: A toxic purine analogue. Inosine dialdehyde inhibits ribonucleotide reductase, resulting in decreased synthesis of DNA, RNA, and proteins, and G2/M-phase cell cycle arrest. This agent also forms stable covalent crosslinks in proteins, thereby inhibiting the activity of enzymes involved in nucleic acid synthesis. (NCI04)

Label: Inosine Dialdehyde

NCI Thesaurus Code: C1136 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0063555  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
9H-Purine-9-acetaldehyde, .alpha.-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R,R)- (8CI)
9H-Purine-9-acetaldehyde, .alpha.-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R-(R*, R*))- (9CI)
9H-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R,R)- (8CI)
9H-purine-9-acetaldehyde, alpha-(1-formyl-2-hydroxyethoxy)-1,6-dihydro-6-oxo-, (R-(R*, R*))- (9CI)
Diglycolaldehyde, .alpha.-(hydroxymethyl)-.alpha.'-(6-hydroxy-9H-purin-9-yl)-
diglycolaldehyde, alpha-(hydroxymethyl)-alpha'-(6-hydroxy-9H-purin-9-yl)
Inosine Dialdehyde
Inosine dialdehyde

External Source Codes: 
CAS Registry Number 23590-99-0 (see NLM ChemIDplus info)
NSC Code 118994 (see NCI DTP info)
PDQ Closed Trial Search ID 39218
PDQ Open Trial Search ID 39218 (check for NCI PDQ open clinical trial info)
UMLS CUI C0063555

Other Properties:
     Name Value (qualifiers indented underneath)
code C1136
Legacy_Concept_Name Inosine_Dialdehyde
Semantic_Type Nucleic Acid, Nucleoside, or Nucleotide
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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