|Indole-3-Carbinol (Code C1135)|
|Terms & Properties|
Preferred Name: Indole-3-Carbinol
Definition: A naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, a natural compound present in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. Indole-3-carbinol scavenges free radicals and induces various hepatic cytochrome P450 monooxygenases. Specifically, this agent induces the hepatic monooxygenase cytochrome P4501A1 (CYP1A1), resulting in increased 2-hydroxylation of estrogens and increased production of the chemoprotective estrogen 2-hydroxyestrone.
CRCH Definition: An indole with a carbinol group (-C2OH) attached at the 3 position of the pyrrole ring. The chemical structure is C1=CC=C2C(=C1)C(=CN2)CO.
NCI-GLOSS Definition: A substance that is being studied as a cancer prevention drug. It is found in cruciferous vegetables.
Display Name: Indole-3-Carbinol
NCI Metathesaurus Link: C0063491 (see NCI Metathesaurus info)
Synonyms & Abbreviations: (see Synonym Details)
External Source Codes:
|CAS Registry Number||700-06-1 (see NLM ChemIDplus info)|
|ChEBI ID||CHEBI:24814 (see ChEBI info)|
|PDQ Closed Trial Search ID||38058|
|PDQ Open Trial Search ID||38058 (check for NCI PDQ open clinical trial info)|
|Name||Value (qualifiers indented underneath)|
Additional Concept Data:
|Defined Fully by Roles: No|