skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Indole-3-Carbinol (Code C1135)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Indole-3-Carbinol

Definition: A naturally occurring, orally available cleavage product of the glucosinolate glucobrassicanin, a natural compound present in a wide variety of plant food substances including members of the family Cruciferae with antioxidant and potential chemopreventive properties. Indole-3-carbinol scavenges free radicals and induces various hepatic cytochrome P450 monooxygenases. Specifically, this agent induces the hepatic monooxygenase cytochrome P4501A1 (CYP1A1), resulting in increased 2-hydroxylation of estrogens and increased production of the chemoprotective estrogen 2-hydroxyestrone.

CRCH Definition: An indole with a carbinol group (-C2OH) attached at the 3 position of the pyrrole ring. The chemical structure is C1=CC=C2C(=C1)C(=CN2)CO.

NCI-GLOSS Definition: A substance that is being studied as a cancer prevention drug. It is found in cruciferous vegetables.

Display Name: Indole-3-Carbinol

Label: Indole-3-Carbinol

NCI Thesaurus Code: C1135 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0063491  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1H-indole-3-methanol
3-Hydroxymethylindole
I3C
Indole-3-Carbinol
Indole-3-carbinol
indole-3-carbinol
Indole-3-methanol

External Source Codes: 
CAS Registry Number 700-06-1 (see NLM ChemIDplus info)
ChEBI ID CHEBI:24814 (see ChEBI info)
PDQ Closed Trial Search ID 38058
PDQ Open Trial Search ID 38058 (check for NCI PDQ open clinical trial info)
UMLS CUI C0063491

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C9H9NO
code C1135
Contributing_Source CRCH
Contributing_Source CTRP
Legacy_Concept_Name Indole-3-Carbinol
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1135

Mainbox Bottom