skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Nrf2 Activator RTA 408 (Code C113443)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Nrf2 Activator RTA 408

Definition: A member of the synthetic oleanane triterpenoid class of compounds and an activator of nuclear factor erythroid 2 [NF-E2]-related factor 2 (Nrf2, Nfe2l2), with potential chemopreventive activity. Upon administration, RTA 408 activates the cytoprotective transcription factor Nrf2. In turn, Nrf2 translocates to the nucleus, dimerizes with a small Maf protein (sMaf), and binds to the antioxidant response element (ARE). This induces the expression of a number of cytoprotective genes, including NAD(P)H quinone oxidoreductase 1 (NQO1), sulfiredoxin 1 (Srxn1), heme oxygenase-1 (HO1, HMOX1), superoxide dismutase 1 (SOD1), gamma-glutamylcysteine synthetase (gamma-GCS), thioredoxin reductase-1 (TXNRD1), glutathione S-transferase (GST), glutamate-cysteine ligase catalytic subunit (Gclc) and glutamate-cysteine ligase regulatory subunit (Gclm), and increases the synthesis of the antioxidant glutathione (GSH). Nrf2, a leucine zipper transcription factor, plays a key role in the maintenance of redox balance and cytoprotection against oxidative stress.

Display Name: Nrf2 Activator RTA 408

Label: Nrf2 Activator RTA 408

NCI Thesaurus Code: C113443 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3827059  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Nrf2 Activator RTA 408
RTA 408

External Source Codes: 
PDQ Closed Trial Search ID 756624
PDQ Open Trial Search ID 756624 (check for NCI PDQ open clinical trial info)
UMLS CUI C3827059

Other Properties:
     Name Value (qualifiers indented underneath)
code C113443
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113443

Mainbox Bottom