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Version: 17.06d (Release date: 2017-06-26)
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Acalabrutinib (Code C113442)

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Terms & Properties

Preferred Name: Acalabrutinib

Definition: An orally available inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, acalabrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways. This leads to an inhibition of the growth of malignant B cells that overexpress BTK. BTK, a member of the src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B lymphocyte development, activation, signaling, proliferation and survival.

Display Name: Acalabrutinib

Label: Acalabrutinib

NCI Thesaurus Code: C113442 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C4078312  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Acalabrutinib
ACALABRUTINIB
ACP-196
Benzamide, 4-(8-Amino-3-((2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl)imidazo(1,5-a)pyrazin-1-yl)-N-2-pyridinyl-
Bruton Tyrosine Kinase Inhibitor ACP-196

External Source Codes: 
CAS Registry Number 1420477-60-6 (see NLM ChemIDplus info)
FDA UNII Code I42748ELQW
PDQ Closed Trial Search ID 756623
PDQ Open Trial Search ID 756623 (check for NCI PDQ open clinical trial info)
UMLS CUI C4078312

Other Properties:
     Name Value (qualifiers indented underneath)
code C113442
Contributing_Source CTRP
Contributing_Source FDA
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113442

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