skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes (Code C113438)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes

Definition: A preparation of autologous, CD34-positive stem/progenitor cells transduced with a lentrivral vector encoding the human adenosine deaminase (ADA) gene under the control of the human elongation factor alpha short promoter (EFS), with potential to restore ADA expression and function. Autologous hematopoietic CD34+ cells are isolated from the patient's own bone marrow, peripheral blood or cord blood, and transduced with the EFS-ADA lentiviral vector ex vivo. Upon re-infusion of the EFS-ADA vector-transduced lymphocytes back into the patient, these cells may both restore ADA activity and prevent severe combined immunodeficiency (SCID) due to ADA deficiency. ADA, an enzyme that catalyzes the deamination of adenosine to inosine, plays a key role in the development and functioning of the immune system.

Label: EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes

NCI Thesaurus Code: C113438 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458232  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EFS-ADA Lentiviral Vector-transduced CD34-positive Autologous Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 756296
PDQ Open Trial Search ID 756296 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458232

Other Properties:
     Name Value (qualifiers indented underneath)
code C113438
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113438

Mainbox Bottom