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Version: 17.06d (Release date: 2017-06-26)
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Innate Defense Regulator SGX942 (Code C113437)

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Terms & Properties

Preferred Name: Innate Defense Regulator SGX942

Definition: A synthetic, 5-amino acid peptide and Innate Defense Regulator (IDR), with immunomodulating, anti-inflammatory, anti-infective and anti-mucositis activities. Upon intravenous administration, SGX942 binds to the ZZ domain of sequestosome-1, also called p62, and activates regulatory signaling transduction pathways involved in the modulation of the innate immune system, such as those mediated by mitogen-activated protein kinase (MAPK) p38 and CCAAT-enhancer-binding protein. This agent promotes monocyte and macrophage recruitment to, and accelerates healing in damaged and infected tissue; it suppresses inflammation through the regulation of the expression of multiple cytokines. This agent may prevent or decrease chemo- or radiotherapy-induced mucositis as well as other types of infection. p62, an intracellular adaptor protein that functions downstream of certain signaling receptors, plays a key role in the activation of the innate immune system.

Display Name: Innate Defense Regulator SGX942

Label: Innate Defense Regulator SGX942

NCI Thesaurus Code: C113437 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458231  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Innate Defense Regulator SGX942
SGX942

External Source Codes: 
PDQ Closed Trial Search ID 756272
PDQ Open Trial Search ID 756272 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458231

Other Properties:
     Name Value (qualifiers indented underneath)
code C113437
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113437

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