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Version: 17.06d (Release date: 2017-06-26)
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Wnt-5a Mimic Hexapeptide Foxy-5 (Code C113435)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Wnt-5a Mimic Hexapeptide Foxy-5

Definition: A formylated, six amino acid, Wnt5a-derived peptide and wnt-5a mimetic with potential anti-metastatic activity. Upon intravenous administration, Wnt-5a mimic hexapeptide foxy-5 binds to and activates the wnt-5a receptors, Frizzled-2 and -5, which activates wnt-5a-mediated signaling. Increased wnt-5a signaling may inhibit endothelial tumor cell migration and invasion. This may decrease metastasis of susceptible tumor cells. However, foxy-5 does not affect tumor cell proliferation or apoptosis. Foxy-5 lacks a heparan sulfate-binding domain and contains a formyl group on its NH2-terminal methionine residue which decreases in vivo degradation. Decreased expression of wnt-5a protein is associated with increased motility of certain tumor cell types.

Label: Wnt-5a Mimic Hexapeptide Foxy-5

NCI Thesaurus Code: C113435 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458229  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Foxy-5
Wnt-5a Mimic Hexapeptide Foxy-5

External Source Codes: 
PDQ Closed Trial Search ID 756269
PDQ Open Trial Search ID 756269 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458229

Other Properties:
     Name Value (qualifiers indented underneath)
code C113435
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113435

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