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Version: 17.06d (Release date: 2017-06-26)
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DKK1-Neutralizing Monoclonal Antibody DKN-01 (Code C113331)

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Terms & Properties

Preferred Name: DKK1-Neutralizing Monoclonal Antibody DKN-01

Definition: A humanized monoclonal antibody directed against Wnt antagonist Dickkopf-1 (DKK1) with potential anti-osteolytic activity. DKK1-neutralizing monoclonal antibody DKN-01 binds to and inhibits DKK1, which restores Wnt pathway signaling. Reactivation of the Wnt signaling pathway may result in the differentiation and activation of osteoblasts within the bone matrix and the reversal of tumor-induced osteolytic disease. Elevated levels of circulating DKK1, a potent Wnt signaling pathway antagonist, is associated with a number of neoplastic diseases.

Display Name: DKK1-Neutralizing Monoclonal Antibody DKN-01

Label: DKK1-Neutralizing Monoclonal Antibody DKN-01

NCI Thesaurus Code: C113331 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458159  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DKK1-Neutralizing Monoclonal Antibody DKN-01
DKN-01

External Source Codes: 
PDQ Closed Trial Search ID 756044
PDQ Open Trial Search ID 756044 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458159

Other Properties:
     Name Value (qualifiers indented underneath)
code C113331
Contributing_Source CTRP
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113331

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