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Version: 17.06d (Release date: 2017-06-26)
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Pegylated Recombinant Human Interleukin-10 AM0010 (Code C113295)

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Terms & Properties

Preferred Name: Pegylated Recombinant Human Interleukin-10 AM0010

Definition: A covalent conjugate of recombinant human interleukin-10 (IL-10) and polyethylene glycol (PEG), with potential anti-fibrotic, anti-inflammatory, immunomodulating and antineoplastic activities. Upon subcutaneous administration, pegylated recombinant human interleukin-10 AM0010 may activate cell-mediated immunity against cancer cells by stimulating the differentiation and expansion of tumor specific cytotoxic CD8+ T cells. This agent may also lower serum cholesterol levels and reduce atherosclerotic plaques by inhibiting the synthesis of pro-inflammatory cytokines, such as Interferon-gamma, IL-2, IL-3, TNF-alpha, and GM-CSF. The PEG moiety inhibits proteolytic breakdown and clearance of AM0010, which prolongs its half-life, extends the duration of its therapeutic effects and allows less frequent dosing.

Label: Pegylated Recombinant Human Interleukin-10 AM0010

NCI Thesaurus Code: C113295 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458142  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AM0010
PEG-rHuIL-10 AM0010
Pegylated Recombinant Human Interleukin-10 AM0010

External Source Codes: 
PDQ Closed Trial Search ID 756011
PDQ Open Trial Search ID 756011 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458142

Other Properties:
     Name Value (qualifiers indented underneath)
code C113295
Semantic_Type Amino Acid, Peptide, or Protein
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113295

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