skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
P-p68 Inhibitor RX-5902 (Code C113293)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: P-p68 Inhibitor RX-5902

Definition: An orally bioavailable small molecule inhibitor of phosphorylated-p68 RNA helicase (P-p68), with potential anti-proliferative and antineoplastic activity. Upon oral administration, P-p68 inhibitor RX-5902 may both inhibit the activity of the anti-apoptotic B-cell lymphoma 2 (Bcl-2) protein and facilitate the induction of cyclin-dependent kinase inhibitor 1 (p21). This may prevent G2/M cell cycle progression and lead to growth inhibition in tumor cells. P-p68 is overexpressed in various types of solid tumors but absent in normal tissues, and plays a role in tumor progression and metastasis. p21 is a potent cyclin-dependent kinase inhibitor which regulates cell cycle progression and mediates both growth arrest and cellular senescence.

Display Name: P-p68 Inhibitor RX-5902

Label: P-p68 Inhibitor RX-5902

NCI Thesaurus Code: C113293 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL458140  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
P-p68 Inhibitor RX-5902
RX-5902
Supinoxin

External Source Codes: 
PDQ Closed Trial Search ID 755944
PDQ Open Trial Search ID 755944 (check for NCI PDQ open clinical trial info)
NCI META CUI CL458140

Other Properties:
     Name Value (qualifiers indented underneath)
code C113293
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113293

Mainbox Bottom