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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Human Serum Amyloid P/Pentraxin 2 (Code C113177)

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Terms & Properties

Preferred Name: Recombinant Human Serum Amyloid P/Pentraxin 2

Definition: A fully recombinant form of the human pentraxin 2 (PTX2) protein with potential antifibrotic activity. Upon intravenous administration, recombinant human serum amyloid P/pentraxin 2 (PRM-151) may inhibit myofibroblast generation by preventing the differentiation of circulating monocytes into fibrocytes and profibrotic macrophages. PTX2 is a circulating plasma protein that belongs to the class of pattern recognition receptors (PRR) of the innate immune system.

Display Name: Recombinant Human Serum Amyloid P/Pentraxin 2

Label: Recombinant Human Serum Amyloid P/Pentraxin 2

NCI Thesaurus Code: C113177 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2976397  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
PRM-151
PRM-151/PTX2
Recombinant Human PTX2
Recombinant Human Serum Amyloid P/Pentraxin 2

External Source Codes: 
PDQ Closed Trial Search ID 755555
PDQ Open Trial Search ID 755555 (check for NCI PDQ open clinical trial info)
UMLS CUI C2976397

Other Properties:
     Name Value (qualifiers indented underneath)
code C113177
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113177

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