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Version: 17.06d (Release date: 2017-06-26)
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Folate Receptor-Targeted Tubulysin Conjugate EC1456 (Code C113176)

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Terms & Properties

Preferred Name: Folate Receptor-Targeted Tubulysin Conjugate EC1456

Definition: An injectable targeted small molecule drug conjugate (SMDC) consisting of folate (vitamin B9) covalently linked to the potent mitotic poison and cytotoxic agent, tubulysin B hydrazide (Tub-B-H) with potential antineoplastic activity. Upon administration, the folate moiety of folate receptor-targeted tubulysin conjugate EC1456 preferentially binds to tumor cells expressing folate receptors (FR). After binding to FR, the agent is internalized by tumor cells and the Tub-B-H moiety inhibits the polymerization of tubulin into microtubules. This may lead to both cell cycle arrest and tumor cell apoptosis. FR, the membrane-bound, high-affinity receptor for folate, is overexpressed on a wide range of primary and metastatic human cancers.

Display Name: Folate Receptor-Targeted Tubulysin Conjugate EC1456

Label: Folate Receptor-Targeted Tubulysin Conjugate EC1456

NCI Thesaurus Code: C113176 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL455247  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
EC1456
Folate Receptor-Targeted Tubulysin Conjugate EC1456
Folate Receptor-Targeting Folate-Tubulysin Conjugate EC1456

External Source Codes: 
PDQ Closed Trial Search ID 755557
PDQ Open Trial Search ID 755557 (check for NCI PDQ open clinical trial info)
NCI META CUI CL455247

Other Properties:
     Name Value (qualifiers indented underneath)
code C113176
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113176

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