skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
DACH-Platin Micelle NC-4016 (Code C113175)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: DACH-Platin Micelle NC-4016

Definition: Polymeric micellar nanoparticles containing diaminocyclohexane platinum (DACH-platin or DACH-Pt) with potential antineoplastic activity. DACH-platin micelle NC-4016 is prepared through the formation of a polymer-metal complex between DACH-platin and the polyethylene glycol-poly (glutamic acid) block copolymer, PEG-P(Glu). DACH-platin, an active metabolite of the platinum-based antineoplastic agent oxaliplatin, is highly hydrophobic and toxic when administered systemically. The use of polymeric micelles incorporating DACH-platin may both increase cell permeability and enhance the retention of the agent. This allows an extended half-life in the blood circulation and a selective and high accumulation of DACH-platin at tumor sites. This results in increased anticancer efficacy while reducing side effects due to DACH-platin toxicity. Upon intravenous administration and internalization by tumor cells, DACH-platin binds to and causes both inter- and intra-strand cross-links in DNA, forming platinum adducts and triggering tumor cell apoptosis.

Label: DACH-Platin Micelle NC-4016

NCI Thesaurus Code: C113175 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL455246  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
DACH-Platin Micelle NC-4016
Dach-Platin Micelle NC-4016
DACH-Pt/m NC-4016
Diaminocyclohexane Platinum Micelle NC-4016
NC-4016

External Source Codes: 
PDQ Closed Trial Search ID 755556
PDQ Open Trial Search ID 755556 (check for NCI PDQ open clinical trial info)
NCI META CUI CL455246

Other Properties:
     Name Value (qualifiers indented underneath)
code C113175
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113175

Mainbox Bottom