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Version: 17.06d (Release date: 2017-06-26)
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Recombinant Cell-Surface Anchored Sialidase DAS181 (Code C113163)

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Terms & Properties

Preferred Name: Recombinant Cell-Surface Anchored Sialidase DAS181

Definition: A recombinant sialidase fusion protein composed of a sialidase catalytic domain derived from Actinomyces viscosus, a constituent of the normal oral and gastrointestinal flora in humans, fused to a cell surface-anchoring domain, with potential anti-viral activity. Following administration by oral inhalation, DAS181 proteolytically removes sialic acid from the airway epithelium, which inhibits viral binding to and internalization by cells of the respiratory epithelium and prevents viral replication. The cell surface anchoring-domain of this agent may increase retention time and drug potency. Sialic acids in the respiratory tract are used by influenza and parainfluenza viruses to invade airway epithelial cells.

Display Name: Recombinant Cell-Surface Anchored Sialidase DAS181

Label: Recombinant Cell-Surface Anchored Sialidase DAS181

NCI Thesaurus Code: C113163 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C2003387  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
273-666-Neuraminidase [273-Methionine] (Actinomyces viscosus Clone DAS181) Fusion Protein With 125-145-Preproamphiregulin (Human)
DAS181
DAS181-F02
Fludase
Recombinant Cell-Surface Anchored Sialidase DAS181

External Source Codes: 
CAS Registry Number 946032-08-2 (see NLM ChemIDplus info)
PDQ Closed Trial Search ID 755932
PDQ Open Trial Search ID 755932 (check for NCI PDQ open clinical trial info)
UMLS CUI C2003387

Other Properties:
     Name Value (qualifiers indented underneath)
code C113163
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113163

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