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Version: 17.06d (Release date: 2017-06-26)
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Spleen Tyrosine Kinase Inhibitor TAK-659 (Code C113162)

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Terms & Properties

Preferred Name: Spleen Tyrosine Kinase Inhibitor TAK-659

Definition: An inhibitor of spleen tyrosine kinase (syk), with potential anti-inflammatory, immunomodulating, and antineoplastic activities. Spleen tyrosine kinase inhibitor TAK-659 may inhibit the activity of syk, which abrogates downstream B-cell receptor (BCR) signaling and leads to an inhibition of B-cell activation, chemotaxis, adhesion and proliferation. Syk, a BCR-associated non-receptor tyrosine kinase that mediates diverse cellular responses, including proliferation, differentiation, and phagocytosis, is expressed in hematopoietic tissues and is often overexpressed in hematopoietic malignancies.

Display Name: Spleen Tyrosine Kinase Inhibitor TAK-659

Label: Spleen Tyrosine Kinase Inhibitor TAK-659

NCI Thesaurus Code: C113162 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL455236  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Spleen Tyrosine Kinase Inhibitor TAK-659
Spleen Tyrosine Kinase Inhibitor TAK659
syk-Inhibitor TAK-659
syk-Inhibitor TAK659
syk Inhibitor TAK-659
syk Inhibitor TAK659
TAK-659
TAK659

External Source Codes: 
PDQ Closed Trial Search ID 755930
PDQ Open Trial Search ID 755930 (check for NCI PDQ open clinical trial info)
NCI META CUI CL455236

Other Properties:
     Name Value (qualifiers indented underneath)
code C113162
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C113162

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