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Version: 17.12d (Release date: 2017-12-26)
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Leflunomide (Code C1128)

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Terms & Properties

Preferred Name: Leflunomide

Definition: A derivative of isoxazole used for its immunosuppressive and anti-inflammatory properties. As a prodrug, leflunomide is converted to an active metabolite, A77 1726, which blocks dihydroorotate dehydrogenase, a key enzyme of de novo pyrimidine synthesis, thereby preventing the expansion of activated T lymphocytes. This agent also inhibits various protein tyrosine kinases, such as protein kinase C (PKC), thereby inhibiting cell proliferation. (NCI04)

NCI-GLOSS Definition: An anticancer drug that works by inhibiting a cancer cell growth factor.

Display Name: Leflunomide

Label: Leflunomide

NCI Thesaurus Code: C1128 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0063041  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Isoxazolecarboxamide, 5-Methyl-N-(4-(trifluoromethyl)phenyl)-

External Source Codes: 
CAS Registry Number 75706-12-6 (see NLM ChemIDplus info)
ChEBI ID CHEBI:6402 (see ChEBI info)
NSC Code 677411 (see NCI DTP info)
PDQ Closed Trial Search ID 42253
PDQ Open Trial Search ID 42253 (check for NCI PDQ open clinical trial info)
UMLS CUI C0063041

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C12H9F3N2O2
code C1128
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Leflunomide
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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