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Version: 17.12d (Release date: 2017-12-26)
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Omacetaxine Mepesuccinate (Code C1127)

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Terms & Properties

Preferred Name: Omacetaxine Mepesuccinate

Definition: A semisynthetic formulation of the cytotoxic plant alkaloid homoharringtonine isolated from the evergreen tree Cephalotaxus with potential antineoplastic activity. Omacetaxine mepesuccinate binds to the 80S ribosome in eukaryotic cells and inhibits protein synthesis by interfering with chain elongation. This agent also induces differentiation and apoptosis in some cancer cell types.

NCI-GLOSS Definition: An anticancer drug that belongs to the plant alkaloid family of drugs.

Display Name: Omacetaxine Mepesuccinate

Label: Omacetaxine Mepesuccinate

NCI Thesaurus Code: C1127 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0062941  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester)
Cephalotaxine, 4-Methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (Ester), [3(R)]- (9CI)
Cephalotaxine, 4-methyl 2-hydroxy-2-(4-hydroxy-4-methylpentyl)butanedioate (ester), [3(R)]- (9CI)
Omacetaxine Mepesuccinate

External Source Codes: 
CAS Registry Number 26833-87-4 (see NLM ChemIDplus info)
FDA UNII Code 6FG8041S5B
NSC Code 141633 (see NCI DTP info)
PDQ Closed Trial Search ID 39476
PDQ Open Trial Search ID 39476 (check for NCI PDQ open clinical trial info)
UMLS CUI C0062941

Other Properties:
     Name Value (qualifiers indented underneath)
Chemical_Formula C29H39NO9
code C1127
Contributing_Source CTRP
Contributing_Source FDA
Legacy_Concept_Name Homoharringtonine
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: Yes  


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