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Version: 17.06d (Release date: 2017-06-26)
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BET Inhibitor RO6870810 (Code C112500)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: BET Inhibitor RO6870810

Definition: A small molecule inhibitor of the BET (Bromodomain and Extra-Terminal) family of bromodomain-containing proteins with potential antineoplastic activity. Upon administration, the BET inhibitor RO6870810 binds to the acetylated lysine recognition motifs found in the bromodomain of BET proteins, which prevents the interaction between BET proteins and acetylated histones. This interaction disrupts chromatin remodeling and gene expression. Prevention of the expression of certain growth-promoting genes may lead to an inhibition of tumor cell growth. Characterized by a tandem repeat of bromodomains at the N-terminus, BET proteins, comprised of BRD2, BRD3, BRD4 and BRDT, are transcriptional regulators that play an important role during cellular development and growth.

Display Name: BET Inhibitor RO6870810

Label: BET Inhibitor RO6870810

NCI Thesaurus Code: C112500 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454674  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
BET Inhibitor RO6870810
Bromodomain and Extra-Terminal Protein Inhibitor RO6870810
RG6146
RO6870810
TEN-010

External Source Codes: 
PDQ Closed Trial Search ID 755021
PDQ Open Trial Search ID 755021 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454674

Other Properties:
     Name Value (qualifiers indented underneath)
code C112500
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112500

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