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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Cetuximab-IRDye 800CW (Code C112499)

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Terms & Properties

Preferred Name: Cetuximab-IRDye 800CW

Definition: An immunoconjugate comprised of the recombinant chimeric monoclonal antibody cetuximab conjugated to the N-hydroxysuccinamide (NHS) ester form of the near-infrared (NIR) fluorescent dye IRDye 800CW (cetuximab-IRDye 800) with potential imaging use. The antibody moiety of cetuximab-IRDye 800 binds to the extracellular domain of the epidermal growth factor receptor (EGFR). Upon binding, IRDye 800 may be detected using NIR imaging, which facilitates the visualization and quantification of EGFR-expressing tumor cells. EGFR is a receptor tyrosine kinase that may be overexpressed on the cell surfaces of various tumor types.

Display Name: Cetuximab-IRDye 800CW

Label: Cetuximab-IRDye 800CW

NCI Thesaurus Code: C112499 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454673  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cetuximab-IRDye 800
Cetuximab-IRDye 800CW

External Source Codes: 
PDQ Closed Trial Search ID 755023
PDQ Open Trial Search ID 755023 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C112499
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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