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National Cancer Institute
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Version: 17.12d (Release date: 2017-12-26)
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Extended Release Flucytosine (Code C112498)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Extended Release Flucytosine

Definition: An extended release (ER) oral tablet that contains flucytosine (5-FC), a fluorinated cytosine analog, with antifungal activity and potential anti-cancer activity. Following oral administration of ER 5-FC, the 5-FC is deaminated to its active metabolite 5-fluorouracil (5-FU). 5-FU replaces uracil during RNA synthesis, which consequently inhibits downstream protein synthesis. In addition, 5-FU is metabolized further to 5-fluorodeoxyuridylic acid monophosphate, which inhibits thymidylate synthetase. Inhibition of this enzyme interrupts nucleotide synthesis, DNA replication and cell proliferation. Negative regulation of protein synthesis, DNA replication and cell proliferation can lead to cell death. Following ingestion of ER 5-FC, intravenous injection of a retroviral vector encoding cytosine deaminase (TC 511) at a tumor site may result in higher local concentrations of 5-FU and its metabolites, and increased tumor cell death than other 5-FU treatment regimens.

Display Name: Extended Release Flucytosine

Label: Extended Release Flucytosine

NCI Thesaurus Code: C112498 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454672  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Extended Release 5-FC
Extended Release 5-Fluorocytosine
Extended Release Flucytosine
Extended-Release 5-FC
Extended-Release 5-Fluorocytosine
Extended-Release Flucytosine
Toca FC

External Source Codes: 
PDQ Closed Trial Search ID 755027
PDQ Open Trial Search ID 755027 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C112498
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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