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Version: 17.06d (Release date: 2017-06-26)
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Hepsulfam (Code C1123)

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Terms & Properties

Preferred Name: Hepsulfam

Definition: A bisulfamic ester which is similar in structure to busulfan and belongs to the family of drugs known as alkylsulfonate alkylating agents. Hepsulfam forms covalent linkages with nucleophilic centers in DNA, resulting in depurination, base miscoding, strand scission, DNA-DNA and DNA-protein cross-linking, and cytotoxicity. (NCI04)

Label: Hepsulfam

NCI Thesaurus Code: C1123 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0062540  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
1,7-Heptanediyl Ester Sulfamic Acid
Hepsulfam
HEPSULFAM
Sulfamic acid, 1,7-heptanediyl ester

External Source Codes: 
CAS Registry Number 96892-57-8 (see NLM ChemIDplus info)
NSC Code 329680 (see NCI DTP info)
PDQ Closed Trial Search ID 39454
PDQ Open Trial Search ID 39454 (check for NCI PDQ open clinical trial info)
UMLS CUI C0062540

Other Properties:
     Name Value (qualifiers indented underneath)
code C1123
Legacy_Concept_Name Hepsulfam
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1123

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