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Version: 17.06d (Release date: 2017-06-26)
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Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine (Code C112206)

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Terms & Properties

Preferred Name: Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine

Definition: An autologous chronic lymphocytic leukemia cancer vaccine consisting of patient-specific membrane proteins directly extracted from patient autologous tumor cells and incorporated into liposomes along with Interleukin 2 (IL-2) to produce membrane-patched proteoliposomes, with potential immunostimulating and antineoplastic activities. After subcutaneous injection of the autologous tumor cell proteoliposomes chronic lymphocytic leukemia vaccine, liposomes deliver the encapsulated tumor antigens into the cytosol of antigen presenting cells (APCs). Subsequently, the APCs process the antigens and present antigen-derived peptides to the immune system. This may enhance recognition of tumors by the immune system, and activate both cytotoxic CD8+ T cells and CD4+ helper T cells against tumor cells. IL-2 is incorporated into the vaccine to leverage its ability to expand activated T cells.

Label: Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine

NCI Thesaurus Code: C112206 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454406  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Autologous Tumor Cell Proteoliposome Chronic Lymphocytic Leukemia Vaccine
Oncoquest-CLL Vaccine
Oncoquest-L Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 754522
PDQ Open Trial Search ID 754522 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454406

Other Properties:
     Name Value (qualifiers indented underneath)
code C112206
Semantic_Type Immunologic Factor

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112206

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