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Version: 17.06d (Release date: 2017-06-26)
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Fluorine F 18 Galacto-RGD Peptide (Code C112178)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Fluorine F 18 Galacto-RGD Peptide

Definition: A radiotracer composed of a cyclic Arg-Gly-Asp (RGD) peptide that is conjugated with galactose and radiolabeled with fluorine 18, for potential noninvasive positron emission tomography (PET) imaging of alphaVbeta3 integrin expression. Upon administration, the RGD moiety of the fluorine 18 galacto-RGD peptide selectively binds to alphaVbeta3 integrin. During PET imaging, alphaVbeta3-expressing tumor cells can be visualized and the degree of tumor angiogenesis can be determined. Use of a hydrophilic glycopeptide-based agent may increase retention in the blood and reduce clearance by the liver. This leads to both increased uptake of fluorine 18 galacto-RGD peptide by tumor cells and enhanced PET imaging efficiency, when compared to other agents that are constructed using lipophilic conjugates. AlphaVbeta3 integrin, a cell adhesion and signaling receptor, is upregulated in tumor vessel endothelial cells and has been associated with proliferation of tumor cells, tumor angiogenesis and metastasis.

Label: Fluorine F 18 Galacto-RGD Peptide

NCI Thesaurus Code: C112178 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0965384  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
18F-Galacto-RGD
[18F]Galacto-RGD
Fluorine F 18 Galacto-RGD Peptide
Fluorine F 18 Glycosylated RGD Peptide

External Source Codes: 
PDQ Closed Trial Search ID 754549
PDQ Open Trial Search ID 754549 (check for NCI PDQ open clinical trial info)
UMLS CUI C0965384

Other Properties:
     Name Value (qualifiers indented underneath)
code C112178
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112178

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