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Version: 17.06d (Release date: 2017-06-26)
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HDAC Inhibitor CXD101 (Code C112177)

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Terms & Properties

Preferred Name: HDAC Inhibitor CXD101

Definition: A novel histone deacetylase (HDAC) inhibitor with potential antineoplastic activity. Although the exact therapeutic mechanism of action for CXD101 is not known, oral administration of this agent should inhibit the catalytic activity of HDAC, which results in an accumulation of highly acetylated histones, followed by the induction of chromatin remodeling and an altered pattern of gene expression. HDAC, a family of enzymes upregulated in many tumor types, deacetylates chromatin-associated histone proteins.

Label: HDAC Inhibitor CXD101

NCI Thesaurus Code: C112177 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454389  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
AZD 9468
HDAC Inhibitor CXD101
Histone Deacetylase Inhibitor CXD101

External Source Codes: 
PDQ Closed Trial Search ID 754547
PDQ Open Trial Search ID 754547 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C112177
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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