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Version: 17.06d (Release date: 2017-06-26)
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Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine (Code C112005)

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Terms & Properties

Preferred Name: Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine

Definition: A replication-defective, recombinant adenoviral serotype 5 (Ad5) encoding human guanylyl cyclase C (hGCC) and the synthetic Pan DR epitope (PADRE), with potential antineoplastic and immunomodulating activities. Upon intramuscular administration, the Ad5-hGCC-PADRE vaccine expresses hGCC, which may induce both humoral and cellular immune responses against tumor cells expressing the hGCC antigen. This results in the immune-mediated inhibition of tumor cell proliferation, and leads to tumor death. The hGCC protein is normally restricted to intestinal epithelial cells but is overexpressed by metastatic colorectal tumors. PADRE is a helper T-lymphocyte epitope that is able to augment the magnitude and duration of the cytotoxic T-lymphocyte (CTL) response.

Display Name: Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine

Label: Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine

NCI Thesaurus Code: C112005 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454294  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Ad5-hGCC-PADRE Vaccine
Adenovirus 5-Human Guanylyl Cyclase C-PADRE Vaccine

External Source Codes: 
PDQ Closed Trial Search ID 754260
PDQ Open Trial Search ID 754260 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454294

Other Properties:
     Name Value (qualifiers indented underneath)
code C112005
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112005

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