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Version: 17.06d (Release date: 2017-06-26)
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p70S6K/Akt Inhibitor MSC2363318A (Code C112004)

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Terms & Properties

Preferred Name: p70S6K/Akt Inhibitor MSC2363318A

Definition: An orally available inhibitor of the serine/threonine protein kinases ribosomal protein S6 Kinase (p70S6K) and Akt (protein kinase B), with potential antineoplastic activity. Upon administration, p70S6K/Akt inhibitor MSC2363318A binds to and inhibits the activity of p70S6K and Akt. This prevents the activation of the PI3K/Akt/p70S6K signaling pathway and inhibits tumor cell proliferation in cancer cells that have an overactivated PI3K/Akt/p70S6K signaling pathway. Constitutive activation and dysregulated signaling of the PI3K/Akt/p70S6K pathway are frequently associated with tumorigenesis of many tumor types; targeting multiple kinases in this pathway is more efficacious than targeting a single kinase.

Display Name: p70S6K/Akt Inhibitor MSC2363318A

Label: p70S6K/Akt Inhibitor MSC2363318A

NCI Thesaurus Code: C112004 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454293  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
MSC2363318A
p70S6K/Akt Inhibitor MSC2363318A

External Source Codes: 
PDQ Closed Trial Search ID 754258
PDQ Open Trial Search ID 754258 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454293

Other Properties:
     Name Value (qualifiers indented underneath)
code C112004
Contributing_Source CTRP
Semantic_Type Organic Chemical
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112004

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