skip navigation links
National Cancer Institute
EVS Logo NCI Term Browser Enterprise Vocabulary Services
Terminologies Value Sets Mappings
Version: 17.06d (Release date: 2017-06-26)
SearchBox Top
SearchBox Bottom
Cebranopadol (Code C112002)

Terms & Properties Synonym Details Relationships Mapping View All  
Terms & Properties

Preferred Name: Cebranopadol

Definition: An orally available antagonist of the nociceptin receptor opioid receptor like -1 (ORL-1), with potential analgesic activity. Upon oral administration, cebranopadol binds to ORL-1 and prevents its interaction with nociceptin. This leads to a decrease of nociceptin/ORL-1-mediated signaling and interferes with the sensation of pain, which results in an analgesic effect. Nociceptin is a neuropeptide involved in the regulation of pain.

Label: Cebranopadol

NCI Thesaurus Code: C112002 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3827125  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
Cebranopadol
GRT-6005
GRT6005
GRT 6005
Spiro[cyclohexane-1,1'(3'H)-pyrano[3,4-b]indol]-4-amine, 6'-fluoro-4',9'-dihydro-N,N-dimethyl-4-phenyl-, (1alpha,4beta)-

External Source Codes: 
PDQ Closed Trial Search ID 754238
PDQ Open Trial Search ID 754238 (check for NCI PDQ open clinical trial info)
UMLS CUI C3827125

Other Properties:
     Name Value (qualifiers indented underneath)
code C112002
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C112002

Mainbox Bottom