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Live-attenuated Listeria monocytogenes-encoding EGFRvIII-NY-ESO-1 Vaccine ADU-623 (Code C111998)

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Terms & Properties

Preferred Name: Live-attenuated Listeria monocytogenes-encoding EGFRvIII-NY-ESO-1 Vaccine ADU-623

Definition: A live-attenuated, double-deleted strain of the Gram-positive bacterium Listeria monocytogenes (Lm) encoding a mutant form of the tumor associated antigens, epidermal growth factor receptor (EGFRvIII) and the cancer/testis antigen NY-ESO-1, with potential immunostimulatory and antineoplastic activities. Upon intravenous administration, live-attenuated Listeria monocytogenes encoding EGFRvIII-NY-ESO-1 vaccine targets dendritic cells and expresses EGFRvIII and NY-ESO-1. This promotes both a potent innate immune response and an adaptive immune response involving the recruitment and activation of T lymphocytes against EGFRvIII and NY-ESO-1-expressing tumor cells, which results in tumor cell lysis.

Label: Live-attenuated Listeria monocytogenes-encoding EGFRvIII-NY-ESO-1 Vaccine ADU-623

NCI Thesaurus Code: C111998 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454287  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
ADU-623
Live-attenuated Listeria monocytogenes-encoding EGFRvIII-NY-ESO-1 Vaccine ADU-623

External Source Codes: 
PDQ Closed Trial Search ID 754227
PDQ Open Trial Search ID 754227 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454287

Other Properties:
     Name Value (qualifiers indented underneath)
code C111998
Semantic_Type Bacterium
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111998

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