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Version: 17.06d (Release date: 2017-06-26)
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P-glycoprotein Inhibitor HM30181AK (Code C111994)

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Terms & Properties

Preferred Name: P-glycoprotein Inhibitor HM30181AK

Definition: An inhibitor of the adenosine triphosphate (ATP)-binding cassette (ABC) transporter P-glycoprotein (P-gp), with adjuvant activity. Upon oral administration, P-gp inhibitor HM30181AK selectively binds to and inhibits the multidrug resistance (MDR) efflux pump P-gp, which prevents the efflux of various chemotherapeutic agents from intestinal epithelial cells to the gastrointestinal tract. This leads to an increase in both oral bioavailability and therapeutic efficacy. P-gp prevents the intestinal uptake and intracellular accumulation of various cytotoxic agents. HM30181AK is not systemically absorbed.

Display Name: P-glycoprotein Inhibitor HM30181AK

Label: P-glycoprotein Inhibitor HM30181AK

NCI Thesaurus Code: C111994 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454283  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
4-Oxo-4H-chromene-2-carboxylic acid [2-(2-4-[2-(6,7-dimethoxy-3,4-dihydro-1H-isoquinolin-2-yl)-ethyl]-phenyl-2H-tetrazol-5-yl)-4,5-dimethoxy-phenyl]-amide
P-glycoprotein Inhibitor HM30181AK
Pgp Inhibitor HM30181AK

External Source Codes: 
PDQ Closed Trial Search ID 754065
PDQ Open Trial Search ID 754065 (check for NCI PDQ open clinical trial info)

Other Properties:
     Name Value (qualifiers indented underneath)
code C111994
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  


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