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Version: 17.06d (Release date: 2017-06-26)
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TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes (Code C111992)

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Terms & Properties

Preferred Name: TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes

Definition: A preparation of tumor infiltrating lymphocytes (TILs) that are transduced with a retroviral vector encoding a gene for a dominant-negative form of the transforming growth factor beta (TGFb) receptor, TGFbDNRII, with potential immunomodulating activity. Upon administration, the TGFbDNRII-transduced autologous TILs recognize and kill tumor cells. The expression of TGFbDNRII allows for the TILs to be resistant to TGF-b-mediated inhibition of T cell proliferation and activation, which allows optimal TIL activity. The immunosuppressant TGF-b is produced by tumor cells and plays a key role in the repression of the immune system.

Label: TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes

NCI Thesaurus Code: C111992 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: CL454281  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
TGFbDNRII-transduced Autologous TILs
TGFbDNRII-transduced Autologous Tumor Infiltrating Lymphocytes

External Source Codes: 
PDQ Closed Trial Search ID 754014
PDQ Open Trial Search ID 754014 (check for NCI PDQ open clinical trial info)
NCI META CUI CL454281

Other Properties:
     Name Value (qualifiers indented underneath)
code C111992
Semantic_Type Cell
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111992

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