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Version: 17.06d (Release date: 2017-06-26)
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FGFR Inhibitor Debio 1347 (Code C111988)

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Terms & Properties

Preferred Name: FGFR Inhibitor Debio 1347

Definition: An orally bioavailable inhibitor of the fibroblast growth factor receptor subtypes 1 (FGFR-1), 2 (FGFR-2) and 3 (FGFR-3), with potential antineoplastic activity. FGFR inhibitor debio 1347 binds to and inhibits FGFR-1, -2, and -3, which result in the inhibition of FGFR-mediated signal transduction pathways. This leads to the inhibition of both tumor cell proliferation and angiogenesis, and causes cell death in FGFR-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases upregulated in many tumor cell types, is essential for tumor cellular proliferation, differentiation and survival.

Display Name: FGFR Inhibitor Debio 1347

Label: FGFR Inhibitor Debio 1347

NCI Thesaurus Code: C111988 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C3827127  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CH5183284
Debiopharm 1347
debio 1347
debio 1347-101
FF284
FGFR Inhibitor Debio 1347

External Source Codes: 
PDQ Closed Trial Search ID 753851
PDQ Open Trial Search ID 753851 (check for NCI PDQ open clinical trial info)
UMLS CUI C3827127

Other Properties:
     Name Value (qualifiers indented underneath)
code C111988
Contributing_Source CTRP
Semantic_Type Pharmacologic Substance

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C111988

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