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Version: 17.06d (Release date: 2017-06-26)
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FOLFOX Regimen (Code C11197)

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Terms & Properties

Preferred Name: FOLFOX Regimen

Definition: One of several chemotherapy regimens that include leucovorin calcium (calcium folinate), 5-fluorouracil and oxaliplatin and which may be used in the treatment of advanced-stage and metastatic colorectal cancer. FOLFOX regimens differ in agent dosing and administration schedule and include FOLFOX 4, FOLFOX 6, modified FOLFOX 6 (mFOLFOX 6) and FOLFOX 7.

NCI-GLOSS Definition: An abbreviation for a chemotherapy combination used to treat colorectal cancer that is advanced or has come back. It is also being studied in the treatment of other types of cancer. It includes the drugs leucovorin calcium (folinic acid), fluorouracil, and oxaliplatin. FOLFOX-4, FOLFOX-6, modified FOLFOX-6 (mFOLFOX-6), and FOLFOX-7 are different in the doses of the three drugs and the ways they are given.

Display Name: FOLFOX Regimen

Label: FOLFOX Regimen

NCI Thesaurus Code: C11197 (Search for linked caDSR metadata)  (search value sets)

NCI Metathesaurus Link: C0915342  (see NCI Metathesaurus info)

Synonyms & Abbreviations: (see Synonym Details)
CF/5-FU/L-OHP
Fluorouracil/Leucovorin Calcium/Oxaliplatin
FOLFOX
FOLFOX Regimen
FOLFOX regimen

External Source Codes: 
PDQ Closed Trial Search ID 42512
PDQ Open Trial Search ID 42512 (check for NCI PDQ open clinical trial info)
UMLS CUI C0915342

Other Properties:
     Name Value (qualifiers indented underneath)
code C11197
Contributing_Source CTRP
DesignNote FDA approved as first line treatment of Advanced Colorectal Cancer
Legacy_Concept_Name Fluorouracil_Leucovorin-Calcium_Oxaliplatin
Semantic_Type Therapeutic or Preventive Procedure

Additional Concept Data: 
Defined Fully by Roles: No  

URL: https://ncit.nci.nih.gov/ncitbrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C11197

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